![]() In 222 patients who completed the study, a mean weight reduction of 8.1 kg reduced systolic blood pressure (SBP) by 4.2 mm Hg and diastolic blood pressure (DBP) by 3.3 mm Hg ( P<0.05), which was accompanied by a significant decrease in FPI, pL and aldosterone levels ( P<0.05). Body weight, BMI, BP, fasting plasma glucose (FPG), fasting plasma insulin (FPI), leptin (pL), renin and aldosterone levels were evaluated at baseline and after 6 and 12 months. After 6 months, patients with a BW reduction <5% were excluded. ![]() ![]() Each patient received tailored, low caloric dietary advice. ![]() We enrolled 376 overweight (body mass index (BMI) ⩾25 and <30 kg m −2) stage 1 hypertensive patients in this prospective 12-month trial. We evaluated the effects of body weight (BW) loss on blood pressure (BP) in overweight non-obese patients with stage 1 hypertension. ![]()
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